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EVA FOAMED EXCIPIENT: NOVEL WAY TO DELIVER STEM CELLS, GROWTH FACTORS AND BIOLOGICS FOR CONTROLLED RELEASE APPLICATIONS

Controlled release delivery of therapeutic agents for creating a microenvironment to prevent recurrence of brain tumors following resection is of interest. Ethylene vinyl acetate copolymer (EVA) in an engineered three dimensional microcellular foam microstructure was evaluated for controlled release using 70,000 Dalton and 200,000 Dalton model agents. Controlled release delivery was assessed. An implanted EVA delivery vehicle seeded with therapeutic agents could provide a modified microenvironment suitable for mitigating brain tumor recurrence in patients with glioblastoma multiforme.