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Potential Use of Ethylene Vinyl Acetate Copolymer Excipient in Oral Controlled Release Applications: A Literature Review

Ethylene vinyl acetate (EVA) copolymer has a record of successfully serving the pharmaceutical industry as a controlled release excipient. EVA has shown excellent stability, processability and versatility in the controlled release of selected oral administered drugs via hot melt extrusion.

In this literature review, you will discover:

  • Information on EVA in oral drug delivery
    Many polymers have been used in oral formulations to provide various functions, including controlled release.
  • EVA’s stability and processability
    The EVA system is durable and flexible in processing.
  • Contributing factors of EVA drug release profile
    Studies show the EVA drug release profile can be influenced by many factors.
  • Modifications of EVA for drug release profile tuning
    The work of several research groups illustrates the manipulation of EVA drug release profiles of water soluble APIs by using additives.
  • Data on the Oral toxicity of EVA
    EVA is on the inactive ingredient list for approved non-oral drug products and related biocompatibility data is readily available.